CNS Drug Delivery Technology
Description of the CNS Drug Delivery Technology
The target of NEUWAY´s CNS Drug Delivery Technology is to facilitate the transport of active drug substances through the blood-brain barrier (BBB). The BBB is an epithelium layer surrounding 600 kilometres cranial blood vessels. This layer controls the transport to and from the central nervous system (CNS) and protects our brain from toxins and pathogens. Unfortunately, many drugs are regarded as toxins by the BBB and are prevented to pass the BBB and exert its activity in the brain. This is why many drug candidates for CNS diseases fail in development.
An efficient CNS delivery system for drugs naturally excluded from the CNS by the BBB would allow reviving the therapeutic potential of drug candidates that got stuck in the development pipeline. NEUWAY focuses on the exploitation of its CNS Drug Delivery Platform that can be used to facilitate the transport of active drug substances of different origins into the CNS.
NEUWAY’s CNS Drug Delivery Platform is based on a protein capsule (Engineered Protein Capsule - EnPC™) that allows filling of its lumen with therapeutic active compounds. The EnPC™ consists of one protein that occurs naturally and is biotechnologically manufactured by NEUWAY (see Figure).
Electron microscopy picture of intact biotechnologically produced EnPC™, which can be filled with drugs.
Preclinical Proof-of-Concept was demonstrated using a large molecule that was successfully transported across the BBB into cells of the mouse CNS: A plasmid encoding for Firefly Luciferase packed into NEUWAY`s EnPC™ expressed the Luciferase protein in brain cells and made the animals brain emit photons (see Figure).
Figure: Luciferase activity in mice after intravenous injection (tail vein) of EnPC™ loaded with luciferase plasmid: Left mouse: plasmid alone; right mouse: plasmid-EnPC™
NEUWAY´s proprietary CNS Drug Delivery Platform has the great potential to serve as a vehicle for active drug substances of different origins to pass the blood brain barrier.
NEUWAY´s proprietary CNS Drug Delivery Platform has the great potential to serve as a vehicle for active drug substances of different origins to pass the blood brain barrier and deliver them to their site of action